Because of the regenerative properties found in platelet-rich plasma and thrombin serum, current clinical practice employs various approaches in surgical applications.

Studies

 

  • Research indicates that adult mesenchymal stem cells, osteoblasts, fibroblasts, endothelial cells, and epidermal cells express cell membrane receptors for growth factors present in PRP.

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  • Concentrating these factors locally (at higher concentrations) within the defect significantly enhances the regeneration of corresponding tissues. Due to the prolonged activity of platelets, a single injection is often adequate to initiate permanent tissue healing.

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  • This retrospective study demonstrates that regular use of PRP can markedly decrease the incidence of both deep sternal wound infections (DSWI) and superficial sternal wound infections (SSWI) without any adverse reactions. Moreover, the cost of preventive PRP treatment is notably lower compared to a one-day hospital stay.

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For a more precise description, more clinical data is needed on possible indications such as:

  • Fractures
  • Burr hole fillings
  • Spondylosis - disc replacement
  • Osteonecrosis
  • Pseudoarthrosis
  • All Autologous Minced Cartilage Surgery
  • Matrix augmented bone marrow stimulation

The regenerative capabilities of PRP and ATS can be enhanced biologically by incorporating bone marrow aspirate concentrate (BMC). Depending on the application, a manufacturing license is necessary for BMC use.

Application of BMC in Orthosurgery

 

"Biological and clinical interest in MSC has increased dramatically over the past two decades, as demonstrated by the ever-growing number of research teams studying these cells."

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