What is CELLULAR MATRIX BCT-HA?

RegenLab®'s Cellular Matrix® medical device has the following USPs:
  • It is the only Class III medical device containing a combination of non-crosslinked HA (20 mg/ml, 40 mg total) and PRP. Cellular Matrix® tubes allow the preparation of autologous platelet-rich plasma combined with a non-crosslinked hyaluronic acid in a unique closed-circuit, regulatory approved, patented technology system, producing reproducible, standardised outputs.
  • HA produced by bacterial fermentation, thus free of animal proteins
  • Final preparation is combination of 50% PRP – 50% HA
Hyaluronic acid is a key molecule involved in skin moisture and has a unique property in retaining water.
  • More than 25 years of clinical experience in skin hydration and volume correction
  • Major component of the extracellular Matrix®
  • Binds water and creates volume
  • Stimulates migration and proliferation of cells
Hyaluronic acid seems to improve the activity of several molecules contained in platelet-rich plasma demonstrated by Smith et al., fibrin polymerisation in the presence of HA generates a clot with large pores, which facilitates cell migration. PRP, used independently, regulates repair mechanisms, and reverses the catabolic environment. When used with HA it has a synergistic action.

Benefits of Cellular Matrix®:

  1. Facial Appearance: In a prospective study, 31 patients were treated by mesotherapy with the RegenPRP and HA combination prepared with Cellular Matrix® (CM-PRP-HA) at 0, 1, and 2 months. Clinical benefits were evaluated by FACE-Q scores and biophysical measurements of skin elasticity. Comparison of FACE-Q scores showed significant improvement at 6 months compared with baseline (p=0.03). Similarly, objective biophysical measurements showed significant improvement in skin elasticity (R5) compared to baseline (p=0.036) at 6 months post-treatment. No serious side effects were reported.

  2. Skin Quality: A prospective study with 5 patients evaluated the clinical benefits of the combination of RegenPRP and HA prepared with Cellular Matrix® (CM-PRP-HA) when used as a mesotherapy on the hand and face. Evaluations of skin quality and tone were performed by both the treated subjects and evaluators.
    • A significant improvement was observed on the skin of the hands and face of all subjects, including improvement of skin quality and tone, as well as wrinkle depth after three treatment sessions
  1. Cellular Regeneration: Cellular Matrix® (CM-PRP-HA) can be used either as a stand-alone treatment injected directly into the superficial dermis or together with the deeper injection into the superficial musculoaponeurotic system (SMAS)10-11. HA acts as a bio-scaffold, increasing growth factor residence time in tissue and enhancing cell migration and regeneration. CM-PRP-HA makes the balancing of volume and lift much easier and gives an instant result 9-10-11.
    • The combination of RegenPRP® and HA provides better contouring and seems to accelerate cellular regeneration, making this combination the right tool for skin hydration. As shown by Smith et al, fibrin polymerisation in the presence of HA creates a clot with large pores, which facilitates cell migration.